Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu

The aim of this work was to find whether prevent administration of L-CAR affect pharmacological effect of GAL. As a marker of the effect of tested drugs was chosen determination of activity of AChE. Calorimetric method according to Ellman for determination of cholinesterases was chosen. Activity of...

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Main Author:	Fousová, Jindřiška
Other Authors:	Herink, Josef
Format:	Dissertation
Language:	Czech
Published:	2007
Online Access:	http://www.nusl.cz/ntk/nusl-281172

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spelling	ndltd-nusl.cz-oai-invenio.nusl.cz-2811722017-09-02T04:15:35Z Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu Acetylcholinesterase activity following interaction of galantamine and L-carnitine. Fousová, Jindřiška Herink, Josef Vopršalová, Marie The aim of this work was to find whether prevent administration of L-CAR affect pharmacological effect of GAL. As a marker of the effect of tested drugs was chosen determination of activity of AChE. Calorimetric method according to Ellman for determination of cholinesterases was chosen. Activity of AChE was measured in the hypophysis and brain parts (the frontal cortex, hippocampus, medial septum and basal ganglia) of laboratory rat. L-CAR significantly increased inhibitory effect of higher dose of GAL in hippocampus. In the frontal cortex this increasing was on the limit of statistical significance. The results obtained suggest the benefit of L-CAR and GAL combination in patients with SDAT. 2007 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-281172 cze info:eu-repo/semantics/restrictedAccess
collection	NDLTD
language	Czech
format	Dissertation
sources	NDLTD
description	The aim of this work was to find whether prevent administration of L-CAR affect pharmacological effect of GAL. As a marker of the effect of tested drugs was chosen determination of activity of AChE. Calorimetric method according to Ellman for determination of cholinesterases was chosen. Activity of AChE was measured in the hypophysis and brain parts (the frontal cortex, hippocampus, medial septum and basal ganglia) of laboratory rat. L-CAR significantly increased inhibitory effect of higher dose of GAL in hippocampus. In the frontal cortex this increasing was on the limit of statistical significance. The results obtained suggest the benefit of L-CAR and GAL combination in patients with SDAT.
author2	Herink, Josef
author_facet	Herink, Josef Fousová, Jindřiška
author	Fousová, Jindřiška
spellingShingle	Fousová, Jindřiška Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu
author_sort	Fousová, Jindřiška
title	Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu
title_short	Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu
title_full	Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu
title_fullStr	Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu
title_full_unstemmed	Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu
title_sort	aktivita acetylcholinesterázy po interakci galantaminu a l-karnitinu
publishDate	2007
url	http://www.nusl.cz/ntk/nusl-281172
work_keys_str_mv	AT fousovajindriska aktivitaacetylcholinesterazypointerakcigalantaminualkarnitinu AT fousovajindriska acetylcholinesteraseactivityfollowinginteractionofgalantamineandlcarnitine
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Aktivita acetylcholinesterázy po interakci galantaminu a L-karnitinu

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