Vliv hypolipidemické terapie na endoteliální dysfunkci a časné aterogenní změny ve stěně cévy u experimentálních modelů aterosklerózy II.
Arteriosclerosis is a degenerative disease of blood vessels. It's often being reffered as "20th century disease". Double knockouted mice (apoE/LDL-receptor-double-knockout) represent a new model, which is able to evolve a serious grade of hyperlipidemia and arteriosclerosis. It was di...
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| Format: | Dissertation |
| Language: | Czech |
| Published: |
2007
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| Online Access: | http://www.nusl.cz/ntk/nusl-280146 |
| Summary: | Arteriosclerosis is a degenerative disease of blood vessels. It's often being reffered as "20th century disease". Double knockouted mice (apoE/LDL-receptor-double-knockout) represent a new model, which is able to evolve a serious grade of hyperlipidemia and arteriosclerosis. It was discovered, that in case of apoE/LDLr-DKO mice even ordinary nourishment led to a stronger progression of arteriosclerosis when compared to apoE apoprotein - only - defective mice. Statins (3-hydroxy-3-methyl-glutaryl-coenzyme A-reductase inhibitors) form currently most effective and most widely used group of hypolipidemics with positive effects on serum lipid levels and even on total and cardiovascular mortality in general. Statins decrease mainly levels of total cholesterol and LDL cholesterol. The aim of this study was to verify whether atorvastatin posses similar antiatherogenic effects in apoE/LDL-receptor-deficient-mice as were shown in humans. To that we analyzed blood lipid spectrum, expression of inflammatory markers in atherosclerotic plaques and the size of atherosclerotic lesions. All mice were fed with experimental diet from the age of 8 weeks. The animals were randomly divided in two groups. The control group of the animals was fed with the atherogenic diet only and in the atorvastatin group, the diet was... |
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