Deriváty pyrazinu jako potenciální léčiva I

Title of diploma thesis: Pyrazine derivatives as potential drugs I. Review of actual worldwide problem of tuberculosis and trends in the tuberculosis treatment and chemical recherché were the parts of this work. Novel pyrazine derivatives connected via -CONH- bridge with substituted anilines were sy...

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Main Author:	Klusoňová, Petra
Other Authors:	Doležal, Martin
Format:	Dissertation
Language:	Czech
Published:	2007
Online Access:	http://www.nusl.cz/ntk/nusl-280091

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spelling	ndltd-nusl.cz-oai-invenio.nusl.cz-2800912017-09-02T04:15:35Z Deriváty pyrazinu jako potenciální léčiva I Pyrazine derivates as potential drugs I. Klusoňová, Petra Doležal, Martin Opletalová, Veronika Title of diploma thesis: Pyrazine derivatives as potential drugs I. Review of actual worldwide problem of tuberculosis and trends in the tuberculosis treatment and chemical recherché were the parts of this work. Novel pyrazine derivatives connected via -CONH- bridge with substituted anilines were synthesized. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of twelve newly synthesized compounds were presented. All products were characterized and tested against Mycobacterium tuberculosis strain H37Rv and against eight fungal pathogen strains. Additionally, the study of inhibition of oxygen evolution rate in spinach chloroplasts and reduction of chlorophyll content in the green algae Chlorella vulgaris in the series of prepared compounds were drawn. Structure-activity relationships among the chemical structure, lipophilicity (log P), and their biological activity of the evaluated compounds were discussed as well. 2007 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-280091 cze info:eu-repo/semantics/restrictedAccess
collection	NDLTD
language	Czech
format	Dissertation
sources	NDLTD
description	Title of diploma thesis: Pyrazine derivatives as potential drugs I. Review of actual worldwide problem of tuberculosis and trends in the tuberculosis treatment and chemical recherché were the parts of this work. Novel pyrazine derivatives connected via -CONH- bridge with substituted anilines were synthesized. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of twelve newly synthesized compounds were presented. All products were characterized and tested against Mycobacterium tuberculosis strain H37Rv and against eight fungal pathogen strains. Additionally, the study of inhibition of oxygen evolution rate in spinach chloroplasts and reduction of chlorophyll content in the green algae Chlorella vulgaris in the series of prepared compounds were drawn. Structure-activity relationships among the chemical structure, lipophilicity (log P), and their biological activity of the evaluated compounds were discussed as well.
author2	Doležal, Martin
author_facet	Doležal, Martin Klusoňová, Petra
author	Klusoňová, Petra
spellingShingle	Klusoňová, Petra Deriváty pyrazinu jako potenciální léčiva I
author_sort	Klusoňová, Petra
title	Deriváty pyrazinu jako potenciální léčiva I
title_short	Deriváty pyrazinu jako potenciální léčiva I
title_full	Deriváty pyrazinu jako potenciální léčiva I
title_fullStr	Deriváty pyrazinu jako potenciální léčiva I
title_full_unstemmed	Deriváty pyrazinu jako potenciální léčiva I
title_sort	deriváty pyrazinu jako potenciální léčiva i
publishDate	2007
url	http://www.nusl.cz/ntk/nusl-280091
work_keys_str_mv	AT klusonovapetra derivatypyrazinujakopotencialnilecivai AT klusonovapetra pyrazinederivatesaspotentialdrugsi
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Deriváty pyrazinu jako potenciální léčiva I

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