| Summary: | In this study a new analytical method for determination of endocrine disruptors is pre- sented. The endocrine-disrupting phenomena is an area of growing concern. Potential ef- fects of endocrine-disrupting pollutants on wildlife and humans has been increased. Since 1980s deformities in fish are observed. Compounds associated to these effects include nat- ural compounds, such es estrogens, progestins and phytoestrogens, synthetic estrogens and a wide variety of organic pollutants, inluding pesticides, surfactants and plasticizers. Among them, estrogens are extraordinary due to their high estrogenic potency, with phys- iological active concentrations ranging from fg/ml to pg/ml. Endocrine disruptors might cause breast cancer in woman, abnormalities in the human reproductive system and differ- ent expressions of biological disorders in wildlife such as hermaphroditism, feminization, and decreased fertility. The presence of numerous endocrine-disrupting compounds in sur- face waters and sediment has been primarily atributed to their incomplete removal in the sewage-treatment process. Determination of these chemicals is required in order to assess their environmental impact. A new ultra high performance liquid chromatography/tandem mass spectrometry method (UHPLC-MS/MS) is presented in this study. The...
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