Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody I

• Main Author: Štvrtecká, Jana
• Other Authors: Vejsová, Marcela
• Format: Dissertation
• Language: Czech
• Published: 2010
• Online Access: http://www.nusl.cz/ntk/nusl-279156

Jana Štvrtecká Evaluation of activity of potentional antifungal substances through the use of microdilution broth method I Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralové Medical bioanalytic_____________________________________________________ The aim of this thesis is to evaluate the potencial in vitro antifungal activity of selected drugs synthetised on the Department of Pharmaceutical Chemistry and Drug Control and on the Department of Anorganic and Organic Chemismy on the Faculty of Pharmacy in Hradec králové. For drug testing was used the microdilution broth method. The tested compounds were tested on followed five yeast strains and three filamentous fungi models which are pathogenic for humans: Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E28, Candida glabrata 20/I, Trichosporon beigelii 1188, Aspergillus fumigatus 231, Absidia corymbifera 272, Trichophyton mentagrophytes 445. 80 compounds were divided into 10 groups accorging to their chemical structures: anilides of pyrazin carboxyl acids, arylamin pyrazines, pyrazin carboxyl acid esters, pyrazine-2,3-dinitriles, benzoxazepin-diones, diamides, styryl benzoxazoles, derivatives of (Z)-5-arylmethyliden-2-thioxothiazolidin-4-on, ester derivatives of cholesterol and alcan acids and...