Studium faktorů ovlivňujících hmotnost perorálních kapek

• Main Author: Franzová, Pavla
• Other Authors: Šklubalová, Zdeňka
• Format: Dissertation
• Language: Czech
• Published: 2009
• Online Access: http://www.nusl.cz/ntk/nusl-278943

10 SUMMARY The factors influencing weight of peroral drops were investigated in this dissertation. During this work six commercial available plastic dropper tips for peroral drops and model mixtures of hydrophil solvents were used. It was determined that the most suitable mixture for testing dropper charakteristics (depending on design of dropper tip) was the mixture of five parts of 96% ethanol and ninetyfive parts of purified water or the mixtureof sixty parts of 85% glycerol and forty parts of purified water. The weight of drop was influenced by the diameter of outer orifice of dropper tip. The final weight of drop is also affected by the other charakteristics - inner diameter of dropper part, inner aperture diameter of dropper capilary, design of dropper tip, design of compensatory capilary. The drop weight of mixture of water with glycerol increased with decreasing density of mixture. The reduction of dropper angle from 90ř (vertical) to 45ř (transversal) lead to decisive reduction of drop weight. The uncontrolled wettion of dropper surface by the liquid was observed in some cases. On the base of optimal dispending of peroral drops we should recommend the producer following: there should be the instruction about the right holding of dropper bottle in upright position (upside-down, 90ř vertical)