| Summary: | L, L- L. l_ t__ L- INTRoDacrtoN High peďommce liquid chromatography (HPLC) is the most common method used in commercial malÍlcal laboratories. HPLC in combination with Mss speďIometry (MS) is frequmtly used for the detemination of drugs in hmm plasma md it belongs to gÍoup of methods that enable new md modem modifications. That is why following new trmds, which broadm the field of application of these methods. is so importmt. HPLC with Ms detection (HPLc-Ms) satisfy demmd for automation of detemination of smples from complex matrixes, which lead to elimination of humm enor, decreme of *penditure of maly,tical process md finally hildling potentially dmgerous smples by laboratory stďl Hrghly sensitive methods that do not require time consuming smple pre-teatment ue desired for phmacokinetic (PK) studies. Double MS (Ms/Ms) detection provides drugs identification md hgh sensitivity fol qumtitative detemination- It effectively eliminates inteďerences from endogenous impurities md guďmtees method selectivity at the sme time- Phmacokinetic (PK) studies detemine phmacokinetic chďactgistics of particulr drug that ile thm used to assess the bioequivalence of detemined drug vqsus othď chosm dÍug of the same nafurc' The PK paÍmetqs ďe calculated from the plmma concentrations of the drug detmined by a validated method'...
|
|---|
