Studium vlivu přísady hypromelosy na hmotnost očních kapek

• Main Author: Nováková, Hana
• Other Authors: Šklubalová, Zdeňka
• Format: Dissertation
• Language: Czech
• Published: 2006
• Online Access: http://www.nusl.cz/ntk/nusl-272227

STUDIUM VLIVU PŘÍSADY HYPROMELOSY NA HMOTNOST OČNÍCH KAPEK Hana Nováková Summary In this work, the influence of three factors on the weight of eye drops produced by the compressible plastic bottle: the dropper tip, the dispensing angle, and viscosity of the preparation was studied. All factors produced the significant effect (p  0.05). It was found that plastic tip with smaller diameter produced eye drops of lower weight in comparison to the rubber dropper tip with larger diameter. The change of dispensing angle from 90ř to 45ř led to the decrease in the drop weight produced by both dropper tips tested. Non-linear increase in drop weight was occurred when viscosity increased in consequence to the gradually increased concentration of the 0.00%-0.16%-0.25%-0.50%-0.75%-1.00% hypromellose (HPMC) solution. Statistically significant increase in the weight of the drops was detected for wetted dropper tips, either plastic or rubber, at 0.16% HPMC concentration which corresponded to viscosity of 3 mPas. In contrast, the weight of the drops produced by non-wetted dropper tips was increased above viscosity of 17 mPas corresponding to the 0.50% HPMC concentration.