A baseline evaluation of the cytotoxicity of gold nanoparticles in different types of mammalian cells for future radiosensitization studies

Magister Scientiae (Medical Bioscience) - MSc(MBS) === Recently nanoparticles (NPs) have been introduced and used in combination with therapeutic approaches to develop nanotechnology-enabled medicine. These nanostructures allow for the exploitation of the physiochemical properties which may be benef...

Full description

Bibliographic Details
Main Author: De Bruyn, Shana
Other Authors: de Kock, M.
Language:en
Published: University of the Western Cape 2021
Subjects:
Online Access:http://hdl.handle.net/11394/7951
Description
Summary:Magister Scientiae (Medical Bioscience) - MSc(MBS) === Recently nanoparticles (NPs) have been introduced and used in combination with therapeutic approaches to develop nanotechnology-enabled medicine. These nanostructures allow for the exploitation of the physiochemical properties which may be beneficial in cancer treatment. The use of NPs in nanomedicine has proven successful in modern chemotherapeutics and has demonstrated promising potential in in vivo and in vitro radiosensitization studies. This is a baseline study aimed to determine the cytotoxic effects of AuNPs for potential radiosensitization analysis. The study analysed the effects of different AuNP sizes (30, 50 and 80nm), concentrations (5, 10 and 15 μg/ml) over various time periods in CHOK1 and A549 cells.