Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities

Magister Pharmaceuticae - MPharm === Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are urgently needed due to the surge in resistan...

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Bibliographic Details
Main Author:	Pokomi, Rostand Fankam
Other Authors:	Joubert, Jacques
Language:	en
Published:	University of the Western Cape 2021
Subjects:	Malaria Plasmodium falciparum Chloroquine resistance Drug resistance Cheminformatics
Online Access:	http://hdl.handle.net/11394/7950

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spelling	ndltd-netd.ac.za-oai-union.ndltd.org-uwc-oai-etd.uwc.ac.za-11394-79502021-03-13T05:10:56Z Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities Pokomi, Rostand Fankam Joubert, Jacques Malan, Sarel Egieyeh, Samuel Malaria Plasmodium falciparum Chloroquine resistance Drug resistance Cheminformatics Magister Pharmaceuticae - MPharm Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are urgently needed due to the surge in resistance of the Plasmodium falciparum (the parasite that causes malaria in humans) to existing antimalarial drugs. One approach to circumvent the problem of P. falciparum resistance to antimalarial drugs could be the discovery of novel compounds with unique scaffolds and possibly new mechanisms of action. Natural products (NP) provide a wide diversity of compounds with unique scaffolds, as such, a library of virtual compounds (VC) designed from natural products with antiplasmodial activities (NAA) can be a worthy starting point. 2021-03-09T10:12:51Z 2021-03-09T10:12:51Z 2020 http://hdl.handle.net/11394/7950 en University of the Western Cape University of the Western Cape
collection	NDLTD
language	en
sources	NDLTD
topic	Malaria Plasmodium falciparum Chloroquine resistance Drug resistance Cheminformatics
spellingShingle	Malaria Plasmodium falciparum Chloroquine resistance Drug resistance Cheminformatics Pokomi, Rostand Fankam Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
description	Magister Pharmaceuticae - MPharm === Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are urgently needed due to the surge in resistance of the Plasmodium falciparum (the parasite that causes malaria in humans) to existing antimalarial drugs. One approach to circumvent the problem of P. falciparum resistance to antimalarial drugs could be the discovery of novel compounds with unique scaffolds and possibly new mechanisms of action. Natural products (NP) provide a wide diversity of compounds with unique scaffolds, as such, a library of virtual compounds (VC) designed from natural products with antiplasmodial activities (NAA) can be a worthy starting point.
author2	Joubert, Jacques
author_facet	Joubert, Jacques Pokomi, Rostand Fankam
author	Pokomi, Rostand Fankam
author_sort	Pokomi, Rostand Fankam
title	Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
title_short	Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
title_full	Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
title_fullStr	Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
title_full_unstemmed	Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
title_sort	selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
publisher	University of the Western Cape
publishDate	2021
url	http://hdl.handle.net/11394/7950
work_keys_str_mv	AT pokomirostandfankam selectionsynthesisandevaluationofnoveldruglikecompoundsfromalibraryofvirtualcompoundsdesignedfromnaturalproductswithantiplasmodialactivities
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Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities

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