Design and synthesis of new scaffolds as antiproliferative agents and potential hsp90 inhibitors
Doctor Pharmaceuticae - DPharm === Natural products have been an important source of drugs and novel lead compounds in drug discovery. Their unique scaffolds have led to the synthesis of derivatives that continue to give rise to medicinally relevant agents. Thus, natural product-inspired drugs rep...
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| Language: | en |
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University of Western Cape
2020
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| Online Access: | http://hdl.handle.net/11394/7722 |
| Summary: | Doctor Pharmaceuticae - DPharm === Natural products have been an important source of drugs and novel lead compounds in drug
discovery. Their unique scaffolds have led to the synthesis of derivatives that continue to give rise
to medicinally relevant agents. Thus, natural product-inspired drugs represent a significant
proportion of drugs in the market and with several more in development. Cancer is among the
leading public health problems and a prominent cause of death globally. Chemotherapy has been
important in the management of this disease even though side effects that arise due to lack of
selectivity is still an issue. |
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