Inherited predisposition to breast/ovarian cancer : the frequency and nature of BRCA1 gene mutations in South African families
Breast cancer is the most common cancer in South African women. Approximately 5¬10% of all breast cancer cases are due to an inherited predisposition, resulting from mutations in tumour suppressor genes. The BRCA1 gene on chromosome 17q is one such tumour suppressor gene, that when mutated confers a...
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