Membrane potential and intracellular cyclic AMP as regulators of calcium homeostasis in formyl peptide-activated human neutrophils : lessons from chronic granulomatous disease
Neutrophils playa key role in the systemic inflammatory response which may lead to serious tissue injury and multiple organ dysfunction. In this setting, activated neutrophils, largely in response to tumour necrosis factor-alpha (TNF-α), secrete reactive oxidants, granule proteases and bioactive lip...