THE APPLICATION OF HIGH-RESOLUTION MELTING CURVE ANALYSIS FOR THE DETECTION OF MUTATIONS IN THE BCR-ABL KINASE DOMAIN OF PATIENTS WITH CHRONIC MYELOID LEUKAEMIA
CML is a haematological malignancy that is characterized by the BCR-ABL fusion oncogene that encodes a constitutively active tyrosine kinase. The treatment of choice for CML is a tyrosine kinase inhibitor and molecular monitoring of patients forms an integral part of disease management. When the exp...
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| Format: | Others |
| Language: | en-uk |
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University of the Free State
2013
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| Online Access: | http://etd.uovs.ac.za//theses/available/etd-06142013-152947/restricted/ |