THE SYNTHESIS OF AN INTERNAL STANDARD FOR BICALUTAMIDE

(R,S)-Bicalutamide [N-(4-cyano-3-trifluoromethylphenyl)-α-methyl-α-hydroxy-β-(4- fluorophenylsulfonyl)propanamide], sold as Casodex®, is the leading antiandrogen currently used to treat prostate cancer. It binds to androgen receptors and blocks cancer growth. This work aims to develop internal s...

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Bibliographic Details
Main Author: Jordaan, Maryam Amra
Other Authors: Prof BCB Bezuidenhoudt
Format: Others
Language:en-uk
Published: University of the Free State 2009
Subjects:
Online Access:http://etd.uovs.ac.za//theses/available/etd-04082009-151002/restricted/