Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis

Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis

Includes bibliographical references (leaves 116-122). === Investigation of coordination and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action...

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Main Author: Kuter, David
Other Authors: Egan, Timothy J
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Chemistry
Online Access:http://hdl.handle.net/11427/9562
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-95622020-10-06T05:11:32Z Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis Kuter, David Egan, Timothy J Chibale, Kelly Chemistry Includes bibliographical references (leaves 116-122). Investigation of coordination and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, imidazoles, amines and phenolates with Fe(III)PPIX, and n-stacking interactions of these compounds with protoporphyrin IX (PPIX) and Fe(III)PPIX were measured in 40% (v/v) aq. DMSO by spectrophotometric titration. 2014-11-11T12:58:14Z 2014-11-11T12:58:14Z 2009 Master Thesis Masters MSc http://hdl.handle.net/11427/9562 eng application/pdf University of Cape Town Faculty of Science Department of Chemistry
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Chemistry
spellingShingle Chemistry
Kuter, David
Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
description Includes bibliographical references (leaves 116-122). === Investigation of coordination and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, imidazoles, amines and phenolates with Fe(III)PPIX, and n-stacking interactions of these compounds with protoporphyrin IX (PPIX) and Fe(III)PPIX were measured in 40% (v/v) aq. DMSO by spectrophotometric titration.
author2 Egan, Timothy J
author_facet Egan, Timothy J
Kuter, David
author Kuter, David
author_sort Kuter, David
title Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_short Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_full Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_fullStr Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_full_unstemmed Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_sort towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with fe(iii)ppix by spectroscopy and synthesis
publisher University of Cape Town
publishDate 2014
url http://hdl.handle.net/11427/9562
work_keys_str_mv AT kuterdavid towardsafragmentapproachtohaemozoininhibitingantimalarialsexplorationofcoordinationandpstackinginteractionswithfeiiippixbyspectroscopyandsynthesis
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