Synthesis and anti-HIV activity of [d4U]-spacer-[HI-236] bifinctional HIV-1 reverse transcriptase inhibitors
Includes bibliographical references (leaves 182-190). === This thesis describes the design and synthesis of bifunctional drugs combining anucleoside (d4U) and non-nucleoside (HI-236) reverse transcriptase inhibitor linkedvia different spacers between C-5 of the NRTI and 0-1 of the NNRTI. Three targe...
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| Format: | Doctoral Thesis |
| Language: | English |
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University of Cape Town
2014
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| Online Access: | http://hdl.handle.net/11427/6346 |