Synthesis and antiplasmodial structure-activity relationships for some novel 4-aminoquinolines and 5-chlorobenzimidazoles

Synthesis and antiplasmodial structure-activity relationships for some novel 4-aminoquinolines and 5-chlorobenzimidazoles

Includes bibliographical references. === Two novel 7-substituted 4-aminoalkylated quinolines, Nl,Nl-diethyl-N2-(7-trifuoromethylthio-4-quinolinyl)-1,2-ethanediamine 11 and Nt, Nl-diethyl-N2-(7-trifuoromethoxy-4-quinolinyl)-1,2-ethanediamine 12 were synthesized via a versatile 6-step route and their...

Full description

Bibliographic Details
Main Author:	Van der Merwe, Johannes Dawid
Other Authors:	Hunter, Roger
Format:	Dissertation
Language:	English
Published:	University of Cape Town 2014
Subjects:	Chemistry
Online Access:	http://hdl.handle.net/11427/6285

Similar Items

The in vitro antiplasmodial properties of novel aminoquinolines and metal complexes of thiomethyl and methylthiomethyl ainline derivatives
by: Holland, Shamillah
Published: (2016)

Synthesis and behaviour of 8-aminoquinoline antimalarials
by: Barton, P. F.
Published: (1984)

Synthesis, in vitro Characterization and Applications of Novel 8-Aminoquinoline Fluorescent Probes
by: McQueen, Adonis
Published: (2017)

Anti-cancer and anti-malarial 4-aminoquinoline derivatives : synthesis and solid-state investigations
by: Melo, Candice Soares de
Published: (2014)

The synthesis and metabolism of novel 4-aminoquinoline antimalarials
by: Shone, Alison Emily
Published: (2007)

An investigation of the analytical properties of 8-aminoquinoline /
by: Foris, Anthony
Published: (1965)

The investigation of 8-aminoquinoline as an analytical reagent /
by: Gustin, Vaughn Kenneth
Published: (1963)

Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids
by: Andayi, Warren Andrew
Published: (2015)

Design, Synthesis and Potential Anti-Proliferative Activity of Some Novel 4-Aminoquinoline Derivatives
by: Ghorab Mostafa M., et al.
Published: (2014-09-01)

In vitro metabolism of tetrazole aminoquinolines and derivatives of metergoline and fusidic acid
by: Njoroge, Mathew
Published: (2015)

Synthesis and biological evaluation of some 4-aminoquinoline derivatives as potential antitubercular agents
by: Shankar Alegaon, et al.
Published: (2020-01-01)

QSAR and molecular docking studies of 1,3-dioxoisoindoline-4-aminoquinolines as potent antiplasmodium hybrid compounds
by: Aliyu Wappah Mahmud, et al.
Published: (2020-03-01)

Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation.
by: Pillay, Pamisha
Published: (2014)

Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity
by: Mabotha, Tebogo E
Published: (2014)

Structure-activity relationship studies of 2-phenylbenzimidazoles and related organometallic complexes as antiplasmodial agents
by: Rylands, Laa-iqa
Published: (2019)

Mono- and multinuclear PGM complexes containing thiosemicarbazones synthesis, characterization and antiplasmodial evaluation
by: Adams, Muneebah
Published: (2015)

Correction to: Synthesis and biological evaluation of some 4-aminoquinoline derivatives as potential antitubercular agents
by: Shankar Alegaon, et al.
Published: (2020-02-01)

Excited-state relaxation of some aminoquinolines
by: M. N. Khimich, et al.
Published: (2006-01-01)

Excited-state relaxation of some aminoquinolines
Published: (2006-01-01)

Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives
by: Efeturi A. Onoabedje, et al.
Published: (2020-09-01)

New aminoquinoline antimalarial cysteine protease inhibitors based on the isatin natural product scaffold
by: Ntuli, Nelson Axe
Published: (2014)

Studies on the chemical and physicochemical basis of 4-aminoquinoline accumulation, activity and resistance in Plasmodium falciparum malaria
by: Hawley, Shaun Richard
Published: (1996)

The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents
by: Tukulula, Matshawandile
Published: (2015)

Mono- and polynuclear Ferrocenyl-derived complexes: synthesis, characterisation and biological evaluation as antimycobacterial and antiplasmodial agents
by: Baartzes, Nadia
Published: (2016)

Synthesis, characterization and antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives
by: Hans Raj Bhat, et al.
Published: (2016-09-01)

Development of aminoquinoline-benzimidazole hybrids and their organometallic complexes as antimicrobial agents against Plasmodium falciparum and Mycobacterium tuberculosis
by: Baartzes, Nadia
Published: (2020)

Structural studies on febrifugine and isofebrifugine, alkaloids from Dichroa febrifuga. Studies on 4-quinazolones. Synthesis of some 8-aminoquinolines
by: Phillips, Robert Edward
Published: (1953)

Synthesis, characterization, and molecular docking of novel 4-Aminoquinolines and Salicylaldimine complexes: evaluation as antimalarial and antitumor agents
by: Busa, Asanda V.
Published: (2018)

Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles
by: Matshawandile Tukulula, et al.
Published: (2020-12-01)

Synthesis, pharmacological and solubility evaluation of antiplasmodial pyrido[1,2-a]benzimidazoles with cyclic and functionalized amine side chain substituents
by: Ndubi, Ferdinand Wafula
Published: (2017)

Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies
by: Melis, Diana
Published: (2020)

Synthesis and antimycobacterial activities of certain trifluoromethyl-aminoquinoline derivatives
by: Alka Mital, et al.
Published: (2006-04-01)

Synthesis and Antiplasmodial Activity of Novel Bioinspired Imidazolidinedione Derivatives
by: Anna Jaromin, et al.
Published: (2021-12-01)

Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides
by: Beus Maja, et al.
Published: (2019-06-01)

Synthesis and biological activity of novel 4-aminoquinoline/1,2,3-triazole hybrids against Leishmania amazonensis
by: Nícolas Glanzmann, et al.
Published: (2021-09-01)

Macromolecular 4-aminoquinoline compounds as potential antimalarial drugs
by: Aderibigbe, Atim Blessing
Published: (2011)

The synthesis of poly(sulphur nitride) and some novel 4-phenyl-1,2,3,5-dithiadiazolium compounds
by: Wait, Simon Timothy
Published: (1989)

The synthesis, structure and chemistry of some novel organometallic dendrimers
by: Hearshaw, Meredith Ann
Published: (2014)

Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones
by: Duc Hoàng Lande, et al.
Published: (2021-08-01)

QSAR studies of some side chain modified 7-chloro-4-aminoquinolines as antimalarial agents
by: Nitendra K. Sahu, et al.
Published: (2014-11-01)