The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

Includes bibliographical references. === Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the sam...

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Bibliographic Details
Main Author: Chitapi, Itai
Other Authors: Sewell, Bryan Trevor
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Structural Biology
Online Access:http://hdl.handle.net/11427/4248

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