The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

Includes bibliographical references. === Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the sam...

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Bibliographic Details
Main Author: Chitapi, Itai
Other Authors: Sewell, Bryan Trevor
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Structural Biology
Online Access:http://hdl.handle.net/11427/4248
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-42482020-10-06T05:11:02Z The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 Chitapi, Itai Sewell, Bryan Trevor Sturrock, E D Structural Biology Includes bibliographical references. Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also inactivates the vasodilator bradykinin. The main overall effect of these actions is an increase in blood pressure. Several ACF inhibitors have been developed as drugs for the treatment of myocardial infarction, hypertension, kidney failure and heart failure. 2014-07-30T17:36:13Z 2014-07-30T17:36:13Z 2006 Master Thesis Masters MSc http://hdl.handle.net/11427/4248 eng application/pdf University of Cape Town Faculty of Science Department of Molecular and Cell Biology
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Structural Biology
spellingShingle Structural Biology
Chitapi, Itai
The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
description Includes bibliographical references. === Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also inactivates the vasodilator bradykinin. The main overall effect of these actions is an increase in blood pressure. Several ACF inhibitors have been developed as drugs for the treatment of myocardial infarction, hypertension, kidney failure and heart failure.
author2 Sewell, Bryan Trevor
author_facet Sewell, Bryan Trevor
Chitapi, Itai
author Chitapi, Itai
author_sort Chitapi, Itai
title The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
title_short The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
title_full The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
title_fullStr The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
title_full_unstemmed The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
title_sort structure of testis angiotensin-converting enzyme (tace-g13) in complex with the inhibitor rxpa380
publisher University of Cape Town
publishDate 2014
url http://hdl.handle.net/11427/4248
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