On the humoral mediation of the intestinal phase of gastric secretion

• Main Author: Kester, Ralph Charles
• Format: Doctoral Thesis
• Language: English
• Published: Faculty of Health Sciences 2020
• Subjects: Gastrointestinal Hormones
• Online Access: https://hdl.handle.net/11427/32033

The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anastomosis. The results of many studies in dogs, and recently in man, have demonstrated conclusively that shunt-related gastric hyper-secretion is due to unmasking of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by a brief period of jejunal distension with a balloon.