The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
Bibliography leaves 70-97. === Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions a...
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Online Access: | http://hdl.handle.net/11427/3144 |
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ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-31442020-10-09T05:09:55Z The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene Ndlovu, Matladi N Parker, M Iqbal Medical Biochemistry Bibliography leaves 70-97. Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression. 2014-07-28T14:55:50Z 2014-07-28T14:55:50Z 2002 Master Thesis Masters MSc http://hdl.handle.net/11427/3144 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Medical Biochemistry |
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NDLTD |
language |
English |
format |
Dissertation |
sources |
NDLTD |
topic |
Medical Biochemistry |
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Medical Biochemistry Ndlovu, Matladi N The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
description |
Bibliography leaves 70-97. === Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression. |
author2 |
Parker, M Iqbal |
author_facet |
Parker, M Iqbal Ndlovu, Matladi N |
author |
Ndlovu, Matladi N |
author_sort |
Ndlovu, Matladi N |
title |
The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
title_short |
The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
title_full |
The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
title_fullStr |
The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
title_full_unstemmed |
The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene |
title_sort |
role of dna methylation in transcriptional regulation of the human type 1 alpha 2 collagen (col1a2) gene |
publisher |
University of Cape Town |
publishDate |
2014 |
url |
http://hdl.handle.net/11427/3144 |
work_keys_str_mv |
AT ndlovumatladin theroleofdnamethylationintranscriptionalregulationofthehumantype1alpha2collagencol1a2gene AT ndlovumatladin roleofdnamethylationintranscriptionalregulationofthehumantype1alpha2collagencol1a2gene |
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