The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene

Bibliography leaves 70-97. === Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions a...

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Bibliographic Details
Main Author: Ndlovu, Matladi N
Other Authors: Parker, M Iqbal
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Online Access:http://hdl.handle.net/11427/3144
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-31442020-10-09T05:09:55Z The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene Ndlovu, Matladi N Parker, M Iqbal Medical Biochemistry Bibliography leaves 70-97. Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression. 2014-07-28T14:55:50Z 2014-07-28T14:55:50Z 2002 Master Thesis Masters MSc http://hdl.handle.net/11427/3144 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Medical Biochemistry
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Medical Biochemistry
spellingShingle Medical Biochemistry
Ndlovu, Matladi N
The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
description Bibliography leaves 70-97. === Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression.
author2 Parker, M Iqbal
author_facet Parker, M Iqbal
Ndlovu, Matladi N
author Ndlovu, Matladi N
author_sort Ndlovu, Matladi N
title The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
title_short The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
title_full The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
title_fullStr The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
title_full_unstemmed The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
title_sort role of dna methylation in transcriptional regulation of the human type 1 alpha 2 collagen (col1a2) gene
publisher University of Cape Town
publishDate 2014
url http://hdl.handle.net/11427/3144
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