Photoaffinity labeling the nucleotide sites of the sarcoplasmic reticulum Ca²⁺-ATPase

Photoaffinity labeling the nucleotide sites of the sarcoplasmic reticulum Ca²⁺-ATPase

We have synthesized a new class of photoaffinity analogs, 2',3'-O-(2,4,6-trinitrophenyl)-8-azido-ATP, -ADP and -AMP (TNP- 8N₃ATP, -ADP and -AMP), and their radiolabeled derivatives, and characterized their interaction with the sarcoplasmic reticulum Ca²⁺-ATPase. The TNP-8N₃-nucleotides wer...

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Bibliographic Details
Main Author: Seebregts, Christopher J
Other Authors: McIntosh, David B
Format: Doctoral Thesis
Language:English
Published: University of Cape Town 2018
Subjects:
Sarcoplasmic reticulum
Adenosinetriphosphatase
Affinity labeling
Binding sites (Biochemistry)
Nucleotides
Ca²⁺-Transporting Atpase
Affinity Labels
Binding sites
Online Access:http://hdl.handle.net/11427/27167

Internet

http://hdl.handle.net/11427/27167

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