Circulating immune complexes in acute rheumatic carditis

The group A beta-haemolytic streptococcus is known to be the aetiologic agent in acute rheumatic fever, but the exact pathogenesis remains obscure. A review of the histopathology of the Aschoff body suggests that the cardiac pathology is a granulomatous hypersensitivity reaction. However the strepto...

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Bibliographic Details
Main Author: Sprenger, Kenneth John
Other Authors: Beatty, David William
Format: Doctoral Thesis
Language:English
Published: University of Cape Town 2018
Subjects:
Online Access:http://hdl.handle.net/11427/27055
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-270552020-07-22T05:07:35Z Circulating immune complexes in acute rheumatic carditis Sprenger, Kenneth John Beatty, David William Antigen-Antibody Complex - immunology - in infancy and childhood Rheumatic Fever - etiology - in infancy and childhood Rheumatic Heart Disease - immunology - in infancy and childhood Immune Complex Di The group A beta-haemolytic streptococcus is known to be the aetiologic agent in acute rheumatic fever, but the exact pathogenesis remains obscure. A review of the histopathology of the Aschoff body suggests that the cardiac pathology is a granulomatous hypersensitivity reaction. However the streptococcus has not been found in the lesions, and the agent responsible for the granuloma has not yet been identified. Circulating immune complexes have previously been measured in some children with acute rheumatic fever. The normal or raised complement components measured by some workers in acute rheumatic fever suggests that the immune complexes may not be complement fixing. Considering that the usual assays for measuring immune complexes depend on complement fixation, the failure of the immune complexes to fix complement might produce false negative results. A physical, non-complement fixing assay (polyethylene glycol precipitation - PEG), was therefore used to measure circulating immune complexes. Results were expressed as total IgG precipitated (g/L), or as a percentage of serum IgG. Immune complexes were also measured by two complement dependent assays, a Clq binding assay (ClqBA), and conglutinin binding assay (CBA). Complexes were assayed in 15 children with acute rheumatic carditis (ARC), 11 with non-active, chronic rheumatic heart disease (CRHD), 13 with acute poststreptococcal glomerulonephritis (APSGN), and 15 normal children and adults (NORMAL). Total haemolytic complement, complement components as well as the complement breakdown product C3d, were measured. 2018-01-29T07:15:15Z 2018-01-29T07:15:15Z 1995 Doctoral Thesis Doctoral MD http://hdl.handle.net/11427/27055 eng application/pdf University of Cape Town Faculty of Health Sciences Department of Paediatrics and Child Health
collection NDLTD
language English
format Doctoral Thesis
sources NDLTD
topic Antigen-Antibody Complex - immunology - in infancy and childhood
Rheumatic Fever - etiology - in infancy and childhood
Rheumatic Heart Disease - immunology - in infancy and childhood
Immune Complex Di
spellingShingle Antigen-Antibody Complex - immunology - in infancy and childhood
Rheumatic Fever - etiology - in infancy and childhood
Rheumatic Heart Disease - immunology - in infancy and childhood
Immune Complex Di
Sprenger, Kenneth John
Circulating immune complexes in acute rheumatic carditis
description The group A beta-haemolytic streptococcus is known to be the aetiologic agent in acute rheumatic fever, but the exact pathogenesis remains obscure. A review of the histopathology of the Aschoff body suggests that the cardiac pathology is a granulomatous hypersensitivity reaction. However the streptococcus has not been found in the lesions, and the agent responsible for the granuloma has not yet been identified. Circulating immune complexes have previously been measured in some children with acute rheumatic fever. The normal or raised complement components measured by some workers in acute rheumatic fever suggests that the immune complexes may not be complement fixing. Considering that the usual assays for measuring immune complexes depend on complement fixation, the failure of the immune complexes to fix complement might produce false negative results. A physical, non-complement fixing assay (polyethylene glycol precipitation - PEG), was therefore used to measure circulating immune complexes. Results were expressed as total IgG precipitated (g/L), or as a percentage of serum IgG. Immune complexes were also measured by two complement dependent assays, a Clq binding assay (ClqBA), and conglutinin binding assay (CBA). Complexes were assayed in 15 children with acute rheumatic carditis (ARC), 11 with non-active, chronic rheumatic heart disease (CRHD), 13 with acute poststreptococcal glomerulonephritis (APSGN), and 15 normal children and adults (NORMAL). Total haemolytic complement, complement components as well as the complement breakdown product C3d, were measured.
author2 Beatty, David William
author_facet Beatty, David William
Sprenger, Kenneth John
author Sprenger, Kenneth John
author_sort Sprenger, Kenneth John
title Circulating immune complexes in acute rheumatic carditis
title_short Circulating immune complexes in acute rheumatic carditis
title_full Circulating immune complexes in acute rheumatic carditis
title_fullStr Circulating immune complexes in acute rheumatic carditis
title_full_unstemmed Circulating immune complexes in acute rheumatic carditis
title_sort circulating immune complexes in acute rheumatic carditis
publisher University of Cape Town
publishDate 2018
url http://hdl.handle.net/11427/27055
work_keys_str_mv AT sprengerkennethjohn circulatingimmunecomplexesinacuterheumaticcarditis
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