Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay

Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay

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The aim of this thesis was to investigate the diagnostic accuracy of Xpert for musculoskeletal TB and for rifampicin resistance against a gold standard of culture or histology. Site of disease, HIV status, and age of patients, and accuracy in spinal compared to extraspinal TB were investigated as se...

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Bibliographic Details
Main Author: Held, Michael
Other Authors: Zar, Heather
Format: Doctoral Thesis
Language:English
Published: University of Cape Town 2016
Subjects:
Orthopaedic Surgery
Online Access:http://hdl.handle.net/11427/20495
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-204952020-07-22T05:07:43Z Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay Held, Michael Zar, Heather Dunn, Robert Orthopaedic Surgery The aim of this thesis was to investigate the diagnostic accuracy of Xpert for musculoskeletal TB and for rifampicin resistance against a gold standard of culture or histology. Site of disease, HIV status, and age of patients, and accuracy in spinal compared to extraspinal TB were investigated as secondary objectives. The overarching hypothesis was that Xpert is more accurate and would provide results faster than the gold standard for musculoskeletal TB, and that it would have a higher yield in HIV infected patients, adult patients, and patients with spinal disease. 2016-07-20T06:59:37Z 2016-07-20T06:59:37Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/20495 eng application/pdf University of Cape Town Faculty of Health Sciences Department of Health and Rehabilitation Sciences
collection NDLTD
language English
format Doctoral Thesis
sources NDLTD
topic Orthopaedic Surgery
spellingShingle Orthopaedic Surgery
Held, Michael
Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
description The aim of this thesis was to investigate the diagnostic accuracy of Xpert for musculoskeletal TB and for rifampicin resistance against a gold standard of culture or histology. Site of disease, HIV status, and age of patients, and accuracy in spinal compared to extraspinal TB were investigated as secondary objectives. The overarching hypothesis was that Xpert is more accurate and would provide results faster than the gold standard for musculoskeletal TB, and that it would have a higher yield in HIV infected patients, adult patients, and patients with spinal disease.
author2 Zar, Heather
author_facet Zar, Heather
Held, Michael
author Held, Michael
author_sort Held, Michael
title Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
title_short Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
title_full Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
title_fullStr Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
title_full_unstemmed Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
title_sort evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert mtb/rif assay
publisher University of Cape Town
publishDate 2016
url http://hdl.handle.net/11427/20495
work_keys_str_mv AT heldmichael evaluationofdiagnosticadvancesinmusculoskeletaltuberculosistheautomatedxpertmtbrifassay
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