Synthesis of side-chain-modified mycothiol analogues incorporating carbazole quinones, and evaluation as inhibitors of enzymes in the Mycobacteria
Mycothiol is found only in Actinobacteria including M. tuberculosis, and appears to play an important role in the bacterium's defence against xenobiotics and oxidative stress. The biosynthetic pathway to this pseudo-disaccharide has been elucidated and a range of mycothiol-dependent enzymes hav...
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| Format: | Doctoral Thesis |
| Language: | English |
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University of Cape Town
2016
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| Online Access: | http://hdl.handle.net/11427/20002 |