Exercise tolerance and skeletal muscle structure and function in patients with chronic obstructive pulminary disease

• Main Author: Coleman, Kirsty Lee
• Other Authors: Derman, Wayne
• Format: Dissertation
• Language: English
• Published: University of Cape Town 2016
• Subjects: Exercise Science
• Online Access: http://hdl.handle.net/11427/17935

Bibliography: pages 143-154. === Exercise intolerance is well documented in patients with chronic obstructive pulmonary disease (COPD). Historically, this exercise intolerance has been attributed to the central factors of lung damage and subsequent heart failure. However, recent evidence suggests that (i) patients with cardiac and renal failure suffer from skeletal muscle (SM) abnormalities that impair exercise tolerance and (ii) patients with chronic obstructive pulmonary disease (COPD) may have metabolic and functional abnormalities of SM. However, no studies have conducted a detailed investigation of SM structure and function and their relation to exercise tolerance in patients with COPD.