Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype
The blood stage of the malarial parasite life-cycle is a vital stage that is believed to be a target for most antimalarial drugs. It is in this stage that host haemoglobin is degraded to provide nutrients for the survival of the parasite. However, a pathway (known as the haem detoxification pathway)...
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| Format: | Dissertation |
| Language: | English |
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University of Cape Town
2015
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| Online Access: | http://hdl.handle.net/11427/15743 |