Identification of a suitable SNP for allele-specific silencing of the disease-causing gene in SCA1 patients in South Africa
Includes bibliographical references (leaves 118-132). === Spinocerebellar ataxia 1 (SCA1) is part of a broader group of dominant neurodegenerative disorders caused by an unstable CAG trinucleotide repeat. There is no known cure for this disease and symptoms worsen progressively culminating in death....
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| Format: | Dissertation |
| Language: | English |
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University of Cape Town
2015
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| Online Access: | http://hdl.handle.net/11427/13436 |