An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds

An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds

Includes abstract.~Includes bibliographical references. === Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal c...

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Bibliographic Details
Main Author: Smith, Muneerah
Other Authors: Parker, Iqbal
Format: Dissertation
Language:English
Published: University of Cape Town 2015
Subjects:
Medical Biochemistry
Online Access:http://hdl.handle.net/11427/12795
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-127952020-10-06T05:11:41Z An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds Smith, Muneerah Parker, Iqbal Kaschula, Catherine Hart Medical Biochemistry Includes abstract.~Includes bibliographical references. Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values. 2015-05-13T14:19:00Z 2015-05-13T14:19:00Z 2014 Master Thesis Masters MSc http://hdl.handle.net/11427/12795 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Medical Biochemistry
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Medical Biochemistry
spellingShingle Medical Biochemistry
Smith, Muneerah
An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
description Includes abstract.~Includes bibliographical references. === Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.
author2 Parker, Iqbal
author_facet Parker, Iqbal
Smith, Muneerah
author Smith, Muneerah
author_sort Smith, Muneerah
title An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
title_short An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
title_full An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
title_fullStr An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
title_full_unstemmed An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
title_sort investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
publisher University of Cape Town
publishDate 2015
url http://hdl.handle.net/11427/12795
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AT smithmuneerah investigationintotheanticancermechanismofgarlicrelatedorganosulfurcompounds
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