Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy

Includes abstract. === Includes bibliographical references (leaves 170-210). === Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little is known about the effect of HIV-in...

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Bibliographic Details
Main Author:	Tena-Coki, Nontobeko Gwendoline
Other Authors:	Hanekom, Willem
Format:	Doctoral Thesis
Language:	English
Published:	University of Cape Town 2015
Subjects:	Infectious Disease and Molecular Medicine
Online Access:	http://hdl.handle.net/11427/11689

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spelling	ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-116892020-07-22T05:07:41Z Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy Tena-Coki, Nontobeko Gwendoline Hanekom, Willem Scriba, Thomas Kampmann, Beate Infectious Disease and Molecular Medicine Includes abstract. Includes bibliographical references (leaves 170-210). Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little is known about the effect of HIV-infection on function and phenotype of T cell responses to mycobacterial antigens in children. This study compares both CD4 and CD8 T cell cytokine expression and memory phenotype in children, following in vitro stimulation with mycobacterial antigens, also contained in novel anti-TB vaccines that are currently undergoing clinical trials. 2015-01-07T13:32:05Z 2015-01-07T13:32:05Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11689 eng application/pdf University of Cape Town Faculty of Health Sciences Institute of Infectious Disease and Molecular Medicine
collection	NDLTD
language	English
format	Doctoral Thesis
sources	NDLTD
topic	Infectious Disease and Molecular Medicine
spellingShingle	Infectious Disease and Molecular Medicine Tena-Coki, Nontobeko Gwendoline Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy
description	Includes abstract. === Includes bibliographical references (leaves 170-210). === Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little is known about the effect of HIV-infection on function and phenotype of T cell responses to mycobacterial antigens in children. This study compares both CD4 and CD8 T cell cytokine expression and memory phenotype in children, following in vitro stimulation with mycobacterial antigens, also contained in novel anti-TB vaccines that are currently undergoing clinical trials.
author2	Hanekom, Willem
author_facet	Hanekom, Willem Tena-Coki, Nontobeko Gwendoline
author	Tena-Coki, Nontobeko Gwendoline
author_sort	Tena-Coki, Nontobeko Gwendoline
title	Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy
title_short	Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy
title_full	Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy
title_fullStr	Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy
title_full_unstemmed	Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy
title_sort	investigations of mycobacteria-specific memoryy/effector t cell responses in hiv infected children receiving antiretroviral therapy
publisher	University of Cape Town
publishDate	2015
url	http://hdl.handle.net/11427/11689
work_keys_str_mv	AT tenacokinontobekogwendoline investigationsofmycobacteriaspecificmemoryyeffectortcellresponsesinhivinfectedchildrenreceivingantiretroviraltherapy
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Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy

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