Increased flux through the hexosamine biosynthetic pathway leads to the induction of acetol-CoA caboxylase gene expression in the heart

Increased flux through the hexosamine biosynthetic pathway leads to the induction of acetol-CoA caboxylase gene expression in the heart

Thesis (MSc)--Stellenbosch University, 2008. === ENGLISH ABSTRACT: Gene expression of the cardiac isoform of acetyl-CoA carboxylase (ACCb) is induced in a glucose-dependent manner. ACCb produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid uptake. Previous studies show that increase...

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Bibliographic Details
Main Author: Imbriolo, Jamie
Other Authors: Essop, M. Faadiel
Format: Others
Language:en_ZA
Published: Stellenbosch : Stellenbosch University 2012
Subjects:
Heart > Metabolism
Insulin resistance
Hyperlipidemia
Fatty acids > Metabolism
Glucose > Metabolism
Hexosamine biosynthetic pathway
Theses > Physiology (Human and animal)
Dissertations > Physiology (Human and animal)
Online Access:http://hdl.handle.net/10019.1/21459

Internet

http://hdl.handle.net/10019.1/21459

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