The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream

The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream

Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate@ (betamethasone 17-valerate, 0.1 %) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were not...

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Main Authors: Magnus, A D, Haigh, J M, Kanfer, I
Format: Others
Language:English
Published: 1981
Online Access:http://hdl.handle.net/10962/d1006322
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-rhodes-vital-63972018-03-06T03:55:31ZThe release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical creamMagnus, A DHaigh, J MKanfer, ISix different vehicles for topical use were used to prepare 50% dilutions of Betnovate@ (betamethasone 17-valerate, 0.1 %) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating that the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.1981Article7 pagespdfvital:6397http://hdl.handle.net/10962/d1006322English
collection NDLTD
language English
format Others
sources NDLTD
description Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate@ (betamethasone 17-valerate, 0.1 %) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating that the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications. === ===
author Magnus, A D
Haigh, J M
Kanfer, I
spellingShingle Magnus, A D
Haigh, J M
Kanfer, I
The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
author_facet Magnus, A D
Haigh, J M
Kanfer, I
author_sort Magnus, A D
title The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
title_short The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
title_full The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
title_fullStr The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
title_full_unstemmed The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
title_sort release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
publishDate 1981
url http://hdl.handle.net/10962/d1006322
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