A statistical evaluation and analysis of mosquito repellent combination

The present product development project was aimed at studying the synergism and/or antagonism amongst various known insect repellent actives with the view to formulating a multi-active repellent product with improved properties when compared to current single-active commercial products. Advanced sta...

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Bibliographic Details
Main Author: Asquith, Ilse Bernadette
Format: Others
Language:English
Published: Nelson Mandela Metropolitan University 2004
Subjects:
Online Access:http://hdl.handle.net/10948/d1015732
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-nmmu-vital-104222017-12-21T04:22:42ZA statistical evaluation and analysis of mosquito repellent combinationAsquith, Ilse BernadetteMosquitoes -- ControlInsect baits and repellentsThe present product development project was aimed at studying the synergism and/or antagonism amongst various known insect repellent actives with the view to formulating a multi-active repellent product with improved properties when compared to current single-active commercial products. Advanced statistical methods were used to identify synergism between individual active substances and to define a formulation as close as possible to the “ideal” formulation. Several mosquito repellent samples were prepared and sent to the South African Bureau of Standards (SABS) in Pretoria to test for their efficiency in repelling mosquitoes. From the results of the repellency tests of the various active combinations, three actives were identified that showed promising signs of synergism. These actives were then studied in further detail to determine their optimum combination. In addition, it was shown that when using a natural flavourant as promoter and incorporating a slow-release agent into formulations for aerosols and lotions, a product is obtained that gives comparable levels of efficiency to current commercial products, but at much reduced levels of active loading. Accelerated stability tests performed on the final combination of the three actives used in the final formulation showed no adverse reactions over a three-week study. These tests shall be repeated once the final application form (lotion, aerosol, etc) and product packing have been decided.Nelson Mandela Metropolitan UniversityFaculty of Science2004ThesisMastersMSc85 leavespdfvital:10422http://hdl.handle.net/10948/d1015732EnglishNelson Mandela Metropolitan University
collection NDLTD
language English
format Others
sources NDLTD
topic Mosquitoes -- Control
Insect baits and repellents
spellingShingle Mosquitoes -- Control
Insect baits and repellents
Asquith, Ilse Bernadette
A statistical evaluation and analysis of mosquito repellent combination
description The present product development project was aimed at studying the synergism and/or antagonism amongst various known insect repellent actives with the view to formulating a multi-active repellent product with improved properties when compared to current single-active commercial products. Advanced statistical methods were used to identify synergism between individual active substances and to define a formulation as close as possible to the “ideal” formulation. Several mosquito repellent samples were prepared and sent to the South African Bureau of Standards (SABS) in Pretoria to test for their efficiency in repelling mosquitoes. From the results of the repellency tests of the various active combinations, three actives were identified that showed promising signs of synergism. These actives were then studied in further detail to determine their optimum combination. In addition, it was shown that when using a natural flavourant as promoter and incorporating a slow-release agent into formulations for aerosols and lotions, a product is obtained that gives comparable levels of efficiency to current commercial products, but at much reduced levels of active loading. Accelerated stability tests performed on the final combination of the three actives used in the final formulation showed no adverse reactions over a three-week study. These tests shall be repeated once the final application form (lotion, aerosol, etc) and product packing have been decided.
author Asquith, Ilse Bernadette
author_facet Asquith, Ilse Bernadette
author_sort Asquith, Ilse Bernadette
title A statistical evaluation and analysis of mosquito repellent combination
title_short A statistical evaluation and analysis of mosquito repellent combination
title_full A statistical evaluation and analysis of mosquito repellent combination
title_fullStr A statistical evaluation and analysis of mosquito repellent combination
title_full_unstemmed A statistical evaluation and analysis of mosquito repellent combination
title_sort statistical evaluation and analysis of mosquito repellent combination
publisher Nelson Mandela Metropolitan University
publishDate 2004
url http://hdl.handle.net/10948/d1015732
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