Force Sensitivity of the Von Willebrand Factor A2 Domain
Von Willebrand factor (VWF) is a multimeric glycoprotein that critically supports platelet aggregation in hemostasis. Disordered VWF function causes both thrombotic and bleeding disorders, and genetic defects in VWF are responsible for von Willebrand’s disease (VWD), the most common inherited bleedi...
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| Language: | en_US |
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Harvard University
2012
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10538 http://nrs.harvard.edu/urn-3:HUL.InstRepos:9888978 |