Defining and Targeting Transcriptional Pathways in Leukemia Stem Cells

Defining and Targeting Transcriptional Pathways in Leukemia Stem Cells

Acute myeloid leukemia (AML) is a clonal neoplastic disorder organized as a cellular hierarchy, with the self-renewing leukemia stem cell (LSC) at the apex. Recurrent mutations in transcription factors (TF) and epigenetic regulators suggest that AML is driven by aberrant transcriptional circuits, b...

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Bibliographic Details
Main Author: Puram, Rishi Venkata
Other Authors: Ebert, Benjamin L.
Language:en_US
Published: Harvard University 2014
Subjects:
Biology
Oncology
Biochemistry
Circadian Rhythm
Clonal Evolution
Leukemia
MLL-AF9
RNA Interference
Single Cell
Online Access:http://dissertations.umi.com/gsas.harvard.inactive:11796
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070042

Internet

http://dissertations.umi.com/gsas.harvard.inactive:11796
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070042

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