The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition

The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) is a fundamental developmental program, which is believed to be reactivated during the progression of in situ carcinoma to aggressive metastatic cancers. Ras-ERK pathway has been shown to play a crucial role in EMT. We have previously shown that ERK2, but not...

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Bibliographic Details
Main Author: Ilter, Didem
Other Authors: Blenis, John
Language:en_US
Published: Harvard University 2014
Subjects:
Cellular biology
DEF motif
EMT
ERK
miR-200
Online Access:http://dissertations.umi.com/gsas.harvard:11407
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274122
id ndltd-harvard.edu-oai-dash.harvard.edu-1-12274122
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spelling ndltd-harvard.edu-oai-dash.harvard.edu-1-122741222015-08-14T15:43:21ZThe Role of ERK2 in Regulating Epithelial-Mesenchymal TransitionIlter, DidemCellular biologyDEF motifEMTERKmiR-200Epithelial-mesenchymal transition (EMT) is a fundamental developmental program, which is believed to be reactivated during the progression of in situ carcinoma to aggressive metastatic cancers. Ras-ERK pathway has been shown to play a crucial role in EMT. We have previously shown that ERK2, but not ERK1, is necessary for RasV12-induced EMT and overexpression of ERK2 is sufficient to promote EMT. ERK2 promotes EMT by regulating several factors, including the upregulation of transcription factors ZEB1/2. ZEB1/2 repress expression of E-cadherin, which is necessary for polar epithelial tissue formations.Blenis, John2014-06-06T16:21:51Z2014-06-062014Thesis or DissertationIlter, Didem. 2014. The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11407http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274122en_USclosed accessHarvard University
collection NDLTD
language en_US
sources NDLTD
topic Cellular biology
DEF motif
EMT
ERK
miR-200
spellingShingle Cellular biology
DEF motif
EMT
ERK
miR-200
Ilter, Didem
The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
description Epithelial-mesenchymal transition (EMT) is a fundamental developmental program, which is believed to be reactivated during the progression of in situ carcinoma to aggressive metastatic cancers. Ras-ERK pathway has been shown to play a crucial role in EMT. We have previously shown that ERK2, but not ERK1, is necessary for RasV12-induced EMT and overexpression of ERK2 is sufficient to promote EMT. ERK2 promotes EMT by regulating several factors, including the upregulation of transcription factors ZEB1/2. ZEB1/2 repress expression of E-cadherin, which is necessary for polar epithelial tissue formations.
author2 Blenis, John
author_facet Blenis, John
Ilter, Didem
author Ilter, Didem
author_sort Ilter, Didem
title The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
title_short The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
title_full The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
title_fullStr The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
title_full_unstemmed The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
title_sort role of erk2 in regulating epithelial-mesenchymal transition
publisher Harvard University
publishDate 2014
url http://dissertations.umi.com/gsas.harvard:11407
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274122
work_keys_str_mv AT ilterdidem theroleoferk2inregulatingepithelialmesenchymaltransition
AT ilterdidem roleoferk2inregulatingepithelialmesenchymaltransition
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