Design and synthesis of dynamically assembling DNA nanostructures

Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed assembly and disassembly pathways. By exploiting the programmable chemistry of b...

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Bibliographic Details
Main Author:	Sadowski, John Paul
Other Authors:	Yin, Peng
Language:	en_US
Published:	Harvard University 2014
Subjects:	Chemistry Nanotechnology Biophysics Bioengineering DNA nanotechnology Molecular self-assembly Nucleic acid design Synthetic biology
Online Access:	http://dissertations.umi.com/gsas.harvard:11272 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744466

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spelling	ndltd-harvard.edu-oai-dash.harvard.edu-1-117444662015-08-14T15:42:50ZDesign and synthesis of dynamically assembling DNA nanostructuresSadowski, John PaulChemistryNanotechnologyBiophysicsBioengineeringDNA nanotechnologyMolecular self-assemblyNanotechnologyNucleic acid designSynthetic biologyKinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed assembly and disassembly pathways. By exploiting the programmable chemistry of base pairing, sophisticated spatial and temporal control have both been demonstrated in DNA self-assembly, but largely as separate pursuits. This dissertation extends a new approach, called developmental self-assembly, that integrates temporal with spatial control by using a prescriptive molecular program to specify the kinetic pathways by which DNA molecules isothermally self-assemble into well-defined three-dimensional geometries.Chemistry and Chemical BiologyYin, Peng2014-02-25T19:01:01Z2014-02-2520132015-02-04T08:30:41ZThesis or DissertationSadowski, John Paul. 2014. Design and synthesis of dynamically assembling DNA nanostructures. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11272http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744466en_USopenhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAAHarvard University
collection	NDLTD
language	en_US
sources	NDLTD
topic	Chemistry Nanotechnology Biophysics Bioengineering DNA nanotechnology Molecular self-assembly Nanotechnology Nucleic acid design Synthetic biology
spellingShingle	Chemistry Nanotechnology Biophysics Bioengineering DNA nanotechnology Molecular self-assembly Nanotechnology Nucleic acid design Synthetic biology Sadowski, John Paul Design and synthesis of dynamically assembling DNA nanostructures
description	Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed assembly and disassembly pathways. By exploiting the programmable chemistry of base pairing, sophisticated spatial and temporal control have both been demonstrated in DNA self-assembly, but largely as separate pursuits. This dissertation extends a new approach, called developmental self-assembly, that integrates temporal with spatial control by using a prescriptive molecular program to specify the kinetic pathways by which DNA molecules isothermally self-assemble into well-defined three-dimensional geometries. === Chemistry and Chemical Biology
author2	Yin, Peng
author_facet	Yin, Peng Sadowski, John Paul
author	Sadowski, John Paul
author_sort	Sadowski, John Paul
title	Design and synthesis of dynamically assembling DNA nanostructures
title_short	Design and synthesis of dynamically assembling DNA nanostructures
title_full	Design and synthesis of dynamically assembling DNA nanostructures
title_fullStr	Design and synthesis of dynamically assembling DNA nanostructures
title_full_unstemmed	Design and synthesis of dynamically assembling DNA nanostructures
title_sort	design and synthesis of dynamically assembling dna nanostructures
publisher	Harvard University
publishDate	2014
url	http://dissertations.umi.com/gsas.harvard:11272 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744466
work_keys_str_mv	AT sadowskijohnpaul designandsynthesisofdynamicallyassemblingdnananostructures
_version_	1716816853277343744

Design and synthesis of dynamically assembling DNA nanostructures

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