Total Synthesis of (−)-Nakadomarin A
A convergent and scalable total synthesis of polycyclic manzamine alkaloid (-)-nakadomarin A is described. Unsaturated bicyclic lactam fragment A was prepared from acrolein in 5 steps, and macrolactam fragment B was prepared from 3-furfural in 7 steps. A double Michael addition reaction (or cyclizat...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:11106 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181224 |