Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons

Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of l...

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Main Author:	Mardinly, Alan Robert
Other Authors:	Greenberg, Michael Eldon
Language:	en_US
Published:	Harvard University 2013
Subjects:	Neurosciences Activity Inhibition Npas4 somatostatin synapse development
Online Access:	http://dissertations.umi.com/gsas.harvard:10739 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11151534

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spelling	ndltd-harvard.edu-oai-dash.harvard.edu-1-111515342015-08-14T15:42:10ZRegulation of Synapse Development by Activity Dependent Transcription in Inhibitory NeuronsMardinly, Alan RobertNeurosciencesActivityInhibitionNpas4somatostatinsynapse developmentNeuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.Greenberg, Michael Eldon2013-10-08T17:32:06Z2013-10-0820132014-06-07T07:30:48ZThesis or DissertationMardinly, Alan Robert. 2013. Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:10739http://nrs.harvard.edu/urn-3:HUL.InstRepos:11151534en_USopenhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAAHarvard University
collection	NDLTD
language	en_US
sources	NDLTD
topic	Neurosciences Activity Inhibition Npas4 somatostatin synapse development
spellingShingle	Neurosciences Activity Inhibition Npas4 somatostatin synapse development Mardinly, Alan Robert Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
description	Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.
author2	Greenberg, Michael Eldon
author_facet	Greenberg, Michael Eldon Mardinly, Alan Robert
author	Mardinly, Alan Robert
author_sort	Mardinly, Alan Robert
title	Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
title_short	Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
title_full	Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
title_fullStr	Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
title_full_unstemmed	Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
title_sort	regulation of synapse development by activity dependent transcription in inhibitory neurons
publisher	Harvard University
publishDate	2013
url	http://dissertations.umi.com/gsas.harvard:10739 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11151534
work_keys_str_mv	AT mardinlyalanrobert regulationofsynapsedevelopmentbyactivitydependenttranscriptionininhibitoryneurons
_version_	1716816781200326656

Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons

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