A Bayesian Semiparametric Joint Model for Longitudinal and Survival Data
Many biomedical studies monitor both a longitudinal marker and a survival time on each subject under study. Modeling these two endpoints as joint responses has potential to improve the inference for both. We consider the approach of Brown and Ibrahim (2003) that proposes a Bayesian hierarchical semi...
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| Format: | Others |
| Language: | English English |
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Florida State University
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| Online Access: | http://purl.flvc.org/fsu/fd/2019_Spring_Wang_fsu_0071E_15120 |
| Summary: | Many biomedical studies monitor both a longitudinal marker and a survival time on each subject under study. Modeling these two endpoints as joint responses has potential to improve the inference for both. We consider the approach of Brown and Ibrahim (2003) that proposes a Bayesian hierarchical semiparametric joint model. The model links the longitudinal and survival outcomes by incorporating the mean longitudinal trajectory as a predictor for the survival time. The usual parametric mixed effects model for the longitudinal trajectory is relaxed by using a Dirichlet process prior on the coefficients. A Cox proportional hazards model is then used for the survival time. The complicated joint likelihood increases the computational complexity. We develop a computationally efficient method by using a multivariate log-gamma distribution instead of Gaussian distribution to model the data. We use Gibbs sampling combined with Neal's algorithm (2000) and the Metropolis-Hastings method for inference. Simulation studies illustrate the procedure and compare this log-gamma joint model with the Gaussian joint models. We apply this joint modeling method to a human immunodeciency virus (HIV) data and a prostate-specific antigen (PSA) data. === A Dissertation submitted to the Department of Statistics in partial fulfillment of the requirements for the degree of Doctor of Philosophy. === Spring Semester 2019. === April 16, 2019. === Bayesian, Gibbs Sampler, Joint model, Longitudinal, Survival === Includes bibliographical references. === Elizabeth H. Slate, Professor Co-Directing Dissertation; Jonathan R. Bradley, Professor Co-Directing Dissertation; Amy M. Wetherby, University Representative; Lifeng Lin, Committee Member. |
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