Mathematical Modeling of Blood Coagulation System with Direct Thrombin Inhibitors for Use in Anticoagulant Therapy

• Other Authors: Mummadavarapu, Srilakshmi (authoraut)
• Format: Others
• Language: English; English
• Published: Florida State University
• Subjects: Chemical engineering
• Online Access: http://purl.flvc.org/fsu/fd/FSU_migr_etd-2195

Heart related diseases have been the leading cause of death in the United States. Approximately 29% of patients die within 1 year after an initial stroke. Anticoagulants have been prescribed to prevent many thrombotic disorders to occur. Anticoagulants have a narrow therapeutic range and the response to a standard dose varies widely both between patients and within patients over time. Changes in patient health, lifestyle or diet can effect changes in the action of the medication. Therefore, patients undergoing oral anticoagulant therapy must have their level of anticoagulation monitored frequently, with dosage adjustment as needed to ensure maximum safety and efficacy. Mathematical models have been predicted to understand the pharmacokinetic behavior of some of these anticoagulant drugs. These models can help in proper monitoring of the drug during anticoagulation therapy. In this work we analyze the dynamics of two basic models which describe the blood coagulation system – The Extrinsic and Intrinsic pathways. The effect of direct thrombin inhibitors on clot formation is studied. With the help of these models we can predict the type of clotting factor disorder the patient is suffering from and the amount of dosage that is to be given. === A Thesis submitted to the Department of Chemical Engineering in partial fulfillment of the requirements for the degree of Master of Science. === Spring Semester, 2005. === February 1, 2005. === PT Time And INR, Direct Thrombin Inhibitors, Blood Clots === Includes bibliographical references. === Srinivas Palanki, Professor Co-Directing Thesis; Yousef Haik, Professor Co-Directing Thesis; Ching-Jen Chen, Committee Member.