A tree based algorithm for predicting protein-DNA binding cores.
轉錄因子(TF) 和轉錄因子結合位點(TFBS) 之間的結合(binding) 是重要的生物信息學課題。高清晰度(長度<10 )的結合核心(binding core) 是從昂貴和費時的三維結構實驗中發現的。因此,我們希望開發一種以序列為基礎的高效計算方法,提供高信心的結合核心作為實驗對象,以提高三維結構實驗的效率。雖然現有很多基於序列的motif辨認算法,但很少有直接針對關聯TF和TFBS的結合核心的。在不使用任何三維結構的結合核心下,最近我們應用了關聯規則挖掘方法於低分辨率的(TF長度>490) 結合序列準確地發掘出高清晰度結合核心,然而,這種方法有幾個缺點。在這篇論文中,我們正...
Other Authors: | Wong, Po Yuen. |
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Format: | Others |
Language: | English Chinese |
Published: |
2012
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549042 http://repository.lib.cuhk.edu.hk/en/item/cuhk-328756 |
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