Study of Golgi polarization during cerebellar Purkinje cell early migration.
神經元定向遷移是中樞神經系統發育必須進行的過程,遷移中的神經元極化細胞支架和分途徑,以達到神經元兩極性。小腦是腦部的運動神經中心,負責調整身體的平衡和肌肉的協調。蒲金氏細胞 (Purkinje cell)是小腦主要的輸出路線,為小腦必不可少的一員。可是,蒲金氏細胞遷移過程的分子機制和細胞機制仍然認知多。高爾基器(Golgi apparatus)是蛋白分途徑中的早期細胞器,它的再定位移動在大腦和小腦神經元的遷移過程中有發生。但是,高爾基器極性在蒲金氏細胞定向遷移中究竟發揮什麼作用仍然未知。在這文研究,我目標研究高爾基器定位和蒲金氏細胞早期遷移的關係。 === 透過免疫熒光成像分析,我發現在蒲金氏...
Other Authors: | Au, Sin Man June. |
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Format: | Others |
Language: | English Chinese |
Published: |
2012
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549201 http://repository.lib.cuhk.edu.hk/en/item/cuhk-328596 |
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