Studies of tumor and MSCs interactions.
惡性腫瘤嚴重威脅著人類的身體健康,其治療也成為人類關注的焦點。傳統的化學療法和放射療法由於缺乏特異性,取得療效的同時往往也帶來較大的毒副作用。隨著對腫瘤發生發展分子機制認識的不斷深入,腫瘤的基因治療已成為攻克和治愈腫瘤最具希望和挑戰的研究領域。近年來研究發現骨髓間充斥幹細胞(MSCs)可被募集至腫瘤或損傷部位并參與腫瘤生長或組織修復,研究證明間充斥幹細胞通過靜脈注入帶瘤鼠(比如乳腺癌、膠質瘤、結腸癌及黑色素瘤)體內后,特異性的分佈于生長中的腫瘤中。這種特異性向腫瘤組織趨化轉移的特性使得骨髓間充斥幹細胞成為腫瘤基因靶向治療的載體的理想細胞。酶蛋白基因如單純皰疹病毒胸苷激酶(HSV-TK)可以使一...
Other Authors: | Zhang, Ting |
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Format: | Others |
Language: | English Chinese |
Published: |
2013
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549810 http://repository.lib.cuhk.edu.hk/en/item/cuhk-328551 |
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