The role of glucose-dependent insulinotropic peptide in adipocyte.
糖尿病是一种呈现流行趋势的代谢紊乱综合症,现如今,全球大约有3.46亿糖尿病患者, 这庞大的数字给各国的公共健康安全支出带来了严重的财政负担。 其中,二型糖尿病(T2DM)占90%。其特点是周围组织的胰岛素抵抗以及后期损伤的胰岛β细胞的功能。在饮食后,小肠会分泌两种肠促胰岛素,葡萄糖依赖性促胰岛素多肽(GIP)和胰高血糖素样肽-1(GLP-1)。两种多肽的主要功能是促进餐后胰岛细胞中胰岛素的分泌,另外他们还可以通过其自身的G蛋白偶联受体,GIPR和GLP-1R发挥其他作用,如葡萄糖依赖性的刺激胰岛素的生成,刺激胰岛β细胞的增殖,抑制细胞的凋亡等。这些功能也使肠促胰岛素成为糖尿病治疗的一种手段,...
Other Authors: | Nie, Yaohui. |
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Format: | Others |
Language: | English Chinese |
Published: |
2012
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549650 http://repository.lib.cuhk.edu.hk/en/item/cuhk-328221 |
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