Design, fabrication and performance evaluation of a tandem time-of-flight mass spectrometer.
基質輔助鐳射解吸電離飛行時間質譜儀是一種重要的儀器被用來對生物樣品做結構分析,通過諸如源後裂解和碰撞誘導裂解兩種方式實現。然而同碰撞誘導裂解比較,源後裂解具有較低的裂解效率。 === 本課題的目的就是提升我們原有的基質輔助鐳射解吸電離飛行時間質譜儀在結構分析方面的能力。對儀器的改造包括(a)將原有的兩級反射器替換為曲線場反射器(b)安裝一個高壓浮地的碰撞室(c)安裝一個同軸的粒子探測器。曲線場反射器和同軸粒子探測器可以實現母離子跟碎片離子的同時監測,碰撞室可以實現母離子的碰撞裂解。在儀器的性能評估實驗中,母離子和所有的源後裂解的碎片離子同時被探測器記錄。在碰撞誘導裂解實驗中,母離子與碰撞氣體分...
Other Authors: | Li, Gang |
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Format: | Others |
Language: | English Chinese |
Published: |
2012
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549445 http://repository.lib.cuhk.edu.hk/en/item/cuhk-328027 |
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