Potential roles of angiotensin ii, glucagon like peptide-1 and vitamin D systems in pancreatic islet function.
胰腺的胰島具有重要的生理功能,表現在系列的荷爾蒙,特別是能夠控制血糖穩態的胰島素的合成和分泌。胰島素的功能受到各種分子信號及環境的調節。在過去的十年裡,腎素血管緊張素系統(RAS)被發現除了調節血壓和體液穩態之外還具有局部性的生理功能。根據我們最近的發現,胰島存在自有的腎素血管緊張素系統並且可能在胰島生理作用和糖尿病方面發揮新穎的作用。同時,越來越多的研究發現一些與臨床相闊的調節因子在胰島的功能和糖尿病中起著關鍵的作用。這些調節因子促進胰島素分泌並且可以調節胰島細胞的生長和凋亡。其中一些調節因子顯示出極大的研究價值。胰高血糖素樣肽-1(GLP-1)能通過它在胰島上的受體改善胰島的功能和血糖的控...
Other Authors: | Cheng, Qianni. |
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Format: | Others |
Language: | English Chinese |
Published: |
2010
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549581 http://repository.lib.cuhk.edu.hk/en/item/cuhk-327950 |
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