Investigating biomedical applications with terahertz pulsed imaging in reflection geometry.

• Other Authors: Sy, Ming Yiu.
• Format: Others
• Language: English; Chinese
• Published: 2011
• Subjects: Terahertz spectroscopy; Diagnostic imaging; Biomedical engineering; Terahertz Imaging; Diagnostic Imaging > methods; Biomedical Engineering
• Online Access: http://library.cuhk.edu.hk/record=b5894772; http://repository.lib.cuhk.edu.hk/en/item/cuhk-327511

Sy, Ming Yiu. === Thesis (M.Phil.)--Chinese University of Hong Kong, 2011. === Includes bibliographical references (p. 95-100). === Abstracts in English and Chinese. === Abstract --- p.1 === Acknowledgments --- p.5 === List of figures --- p.9 === List of tables --- p.13 === List of abbreviations --- p.14 === List of publications and awards --- p.15 === Awards --- p.16 === Chapter Chapter 1 --- Introduction --- p.17 === Chapter 1.1 --- Terahertz radiation --- p.18 === Chapter 1.1.1 --- Terahertz sources --- p.19 === Chapter 1.1.2 --- Terahertz systems --- p.20 === Chapter 1.1.3 --- Reflection and Transmission geometries --- p.21 === Chapter 1.2 --- Terahertz biomedical applications --- p.24 === Chapter 1.2.1 --- Biomolecules --- p.24 === Chapter 1.2.2 --- THz biomedical imaging --- p.25 === Chapter 1.2.3 --- THz Spectroscopy --- p.26 === Chapter 1.3 --- Objectives --- p.26 === Chapter 1.4 --- Structure of this thesis --- p.26 === Chapter Chapter 2 --- Theory and experimental system --- p.28 === Chapter 2.1 --- Theory --- p.28 === Chapter 2.1.1 --- Propagation of electromagnetic field through dielectric media --- p.29 === Chapter 2.1.2 --- A de-noising method --- p.32 === Chapter 2.1.3 --- Baseline calculation --- p.34 === Chapter 2.1.4 --- Frequency-dependent Refractive Index and Absorption Coefficient.. --- p.37 === Chapter 2.2 --- Experimental Configuration --- p.41 === Chapter 2.2.1 --- Terahertz generation and detection --- p.41 === Chapter 2.2.2 --- Configuration of our system --- p.44 === Chapter 2.2.3 --- Hand-held TPI Setup --- p.46 === Chapter 2.3 --- Data Structure --- p.48 === Chapter 2.4 --- Pre-processing and the user interface --- p.49 === Chapter 2.4.1 --- Data pre-processing 1 (Chopping) --- p.49 === Chapter 2.4.2 --- Data pre-processing 2 (Angle selection) --- p.50 === Chapter 2.4.3 --- The user interface for the data processing --- p.52 === Chapter Chapter 3 --- Ex-v/vo experiment: investigating the origin of contrast --- p.54 === Chapter 3.1 --- Liver Cirrhosis --- p.54 === Chapter 3.1.1 --- Liver --- p.54 === Chapter 3.1.2 --- Liver cirrhosis --- p.54 === Chapter 3.1.3 --- The trend of liver cirrhosis --- p.56 === Chapter 3.1.4 --- Technique for diagnosing liver cirrhosis --- p.57 === Chapter 3.2 --- Experiment protocol --- p.58 === Chapter 3.2.1 --- Formalin fixing --- p.58 === Chapter 3.2.2 --- Sample preparation --- p.58 === Chapter 3.2.3 --- Formalin fixing protocol --- p.60 === Chapter 3.2.4 --- Histopathology --- p.61 === Chapter 3.2.5 --- Protocol for measuring sample water content --- p.61 === Chapter 3.3 --- Results and discussion --- p.62 === Chapter 3.3.1 --- Optical parameters of the fresh and fixed samples --- p.62 === Chapter 3.3.2 --- Consistency with previous results --- p.63 === Chapter 3.3.3 --- The relationship between water content and optical parameters --- p.64 === Chapter 3.3.4 --- Conclusion --- p.68 === Chapter Chapter 4 --- In-vivo experiment: imaging of human skin --- p.69 === Chapter 4.1 --- Human skin --- p.69 === Chapter 4.1.1 --- The structure of human skin --- p.69 === Chapter 4.1.2 --- Skin thickness --- p.70 === Chapter 4.1.3 --- The structure and regeneration of stratum corneum --- p.70 === Chapter 4.1.4 --- Stratum corneum related Skin disease --- p.72 === Chapter 4.2 --- Combing reflections of electromagnetic wave --- p.73 === Chapter 4.3 --- Experiment protocol --- p.74 === Chapter 4.3.1 --- THz response of human skin --- p.74 === Chapter 4.3.2 --- Protocol for measuring human skin --- p.75 === Chapter 4.4 --- Results and discussion --- p.76 === Chapter 4.4.1 --- The variation due to the position --- p.76 === Chapter 4.4.2 --- The variation due to the temperature and humidity --- p.78 === Chapter 4.4.3 --- Discussion --- p.79 === Chapter Chapter 5 --- Noise evaluation --- p.80 === Chapter 5.1 --- The main noise source --- p.80 === Chapter 5.2 --- SNR and DR --- p.80 === Chapter 5.2.1 --- Signal to noise ratio (SNR) --- p.80 === Chapter 5.2.2 --- Dynamic range (DR) --- p.81 === Chapter 5.2.3 --- SNRVS DR --- p.82 === Chapter 5.3 --- Simulation of noise impact on the complex refractive index --- p.83 === Chapter 5.3.1 --- Methodology --- p.83 === Chapter 5.3.2 --- SNR: Simulation results and discussions --- p.85 === Chapter 5.3.3 --- DR: Simulation results and discussions --- p.87 === Chapter 5.3.4 --- Conclusion --- p.89 === Chapter Chapter 6 --- Conclusion and future work --- p.90 === Chapter 6.1 --- Conclusion --- p.90 === Chapter 6.1.1 --- A summary of Terahertz pulsed imaging (TPI) techniques --- p.90 === Chapter 6.1.2 --- Our system and calculations --- p.90 === Chapter 6.1.3 --- Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast --- p.91 === Chapter 6.1.4 --- In-v/vo study: skin measurement --- p.91 === Chapter 6.1.5 --- SNR sensitivity --- p.92 === Chapter 6.2 --- Suggestions for future work --- p.92 === Chapter 6.2.1 --- Algorithms --- p.92 === Chapter 6.2.2 --- Understanding the origin of contrast --- p.93 === Chapter 6.2.3 --- Application in cardiovascular diagnosing imaging --- p.93 === Chapter 6.3 --- Concluding remarks --- p.94 === References --- p.95