A cost-effectiveness analysis of the first-line treatment regimens for multiple myeloma in Macao.

• Other Authors: Kuok, Chiu Fai.
• Format: Others
• Language: English; Chinese
• Published: 2009
• Subjects: Multiple myeloma > Treatment; Medical care > Cost effectiveness; Medical care > China > Macau (Special Administrative Region) > Cost effectiveness; Multiple Myeloma > therapy; Cost-Benefit Analysis; Cost-Benefit Analysis > Macau
• Online Access: http://library.cuhk.edu.hk/record=b5894155; http://repository.lib.cuhk.edu.hk/en/item/cuhk-326783

Kuok, Chiu Fai. === Thesis (M.Phil.)--Chinese University of Hong Kong, 2009. === Includes bibliographical references (leaves 139-154). === Abstract and appendix also in Chinese. === Abstract --- p.i === Abstract (in Chinese) --- p.iv === Acknowledgements --- p.vi === Table of Contents --- p.vii === List of Tables --- p.xi === List of Figures --- p.xiv === List of Abbreviations --- p.xv === Chapter Chapter 1 --- Introduction === Chapter 1.1 --- Introduction --- p.1 === Chapter 1.2 --- The Impact of Malignant Diseases and Multiple Myeloma --- p.4 === Chapter 1.3 --- Pharmacoeconomics --- p.6 === Chapter 1.4 --- Macao Healthcare System --- p.9 === Chapter 1.5 --- Study Hypothesis --- p.12 === Chapter 1.6 --- Study Objectives --- p.12 === Chapter 1.7 --- Perspective of the Study --- p.13 === Chapter Chapter 2 --- Literature Review === Chapter 2.1 --- Hematopoietic System --- p.14 === Chapter 2.1.1 --- Specific Blood Cell Lineages and Blood Cells --- p.15 === Chapter 2.1.2 --- Bone Marrow Microenvironment --- p.19 === Chapter 2.2 --- The Hematologic Malignancies --- p.20 === Chapter 2.2.1 --- Leukemia --- p.21 === Chapter 2.2.2 --- Lymphoma --- p.23 === Chapter 2.2.3 --- Plasma Cell Disorders --- p.24 === Chapter 2.3 --- Multiple Myeloma --- p.25 === Chapter 2.3.1 --- Epidemiology --- p.26 === Chapter 2.3.2 --- Pathology --- p.29 === Chapter 2.3.3 --- Clinical Presentation and Disease Complications --- p.31 === Chapter 2.3.4 --- Classification and Diagnostic Criteria --- p.35 === Chapter 2.3.5 --- Disease Staging and Prognosis --- p.42 === Chapter 2.3.6 --- Treatment --- p.45 === Chapter 2.3.6.1 --- Treatment Regimens and Strategies --- p.47 === Chapter 2.3.6.1.1 --- Standard Chemotherapy --- p.48 === Chapter 2.3.6.1.1.1 --- Melphalan-based Regimens --- p.51 === Chapter 2.3.6.1.1.2 --- VAD-based Regimens --- p.52 === Chapter 2.3.6.1.1.3 --- High-dose Glucocorticoid Regimens --- p.53 === Chapter 2.3.6.1.2 --- Treatment Strategies --- p.53 === Chapter 2.3.6.1.2.1 --- Initial Chemotherapy --- p.53 === Chapter 2.3.6.1.2.2 --- High-dose Chemotherapy --- p.55 === Chapter 2.3.6.1.2.3 --- Newer Therapeutic Agents for Multiple Myeloma --- p.58 === Chapter 2.3.6.1.2.4 --- Salvage Chemotherapy --- p.60 === Chapter 2.3.6.2 --- Treatment Responses --- p.63 === Chapter 2.3.6.3 --- Treatment for Disease Complications --- p.66 === Chapter Chapter 3 --- Methodology === Chapter 3.1 --- Study Design --- p.69 === Chapter 3.2 --- Patients Selection Criteria --- p.71 === Chapter 3.2.1 --- For Retrospective Cost Analysis --- p.71 === Chapter 3.2.2 --- For Health-related Quality of Life Measurement --- p.71 === Chapter 3.3 --- Patient Screening --- p.72 === Chapter 3.4 --- Data Collection --- p.72 === Chapter 3.5 --- Overview of Assessment Methods --- p.73 === Chapter 3.5.1 --- Outcomes --- p.73 === Chapter 3.5.2 --- Cost Analysis --- p.74 === Chapter 3.5.3 --- Cost Effectiveness Analysis --- p.74 === Chapter 3.5.4 --- Cost Utility Analysis --- p.75 === Chapter 3.5.5 --- Health-related Quality of Life Assessment --- p.75 === Chapter 3.6 --- Statistical Analysis --- p.76 === Chapter 3.7 --- Ethic approval --- p.77 === Chapter Chapter 4 --- Results === Chapter 4.1 --- Study Population --- p.78 === Chapter 4.1.1 --- Cost and Pharmacoeconomic Analysis --- p.78 === Chapter 4.1.2 --- Health-related Quality of Life Assessment --- p.79 === Chapter 4.2 --- Study Results --- p.81 === Chapter 4.2.1 --- Comparison of All Patients --- p.81 === Chapter 4.2.1.1 --- Differences in Treatment Protocols --- p.81 === Chapter 4.2.1.2 --- Differences in Treatment Responses --- p.82 === Chapter 4.2.1.3 --- Differences in Treatment Outcomes --- p.82 === Chapter 4.2.1.4 --- Differences in Treatment Costs --- p.84 === Chapter 4.2.2 --- Comparison for Patients Treated by Melphalan-based Regimens and VAD-based Regimens --- p.90 === Chapter 4.2.2.1 --- Differences in Treatment Responses --- p.90 === Chapter 4.2.2.2 --- Differences in Treatment Outcomes --- p.90 === Chapter 4.2.2.3 --- Differences in Treatment Costs --- p.93 === Chapter 4.2.3 --- Melphalan-based Regimens Versus VAD-based Regimens by Patients with Different DS Staging --- p.96 === Chapter 4.2.3.1 --- Patients in Stage 3-A MM --- p.96 === Chapter 4.2.3.2 --- Patients in Stage 3-B MM --- p.98 === Chapter 4.2.4 --- Melphalan-based Regimens versus VAD-based Regimens in Patients with Different IS Staging --- p.101 === Chapter 4.2.4.1 --- Patients in Stage I MM --- p.101 === Chapter 4.2.4.2 --- Patients in Stage II MM --- p.104 === Chapter 4.2.4.3 --- Patients in Stage III MM --- p.107 === Chapter 4.2.5 --- Comparison for Patients with and without Transplantation --- p.110 === Chapter 4.2.6 --- Cost-effectiveness Assessment --- p.117 === Chapter 4.2.7 --- Cost-utility Assessment --- p.118 === Chapter 4.2.8 --- Sensitivity Analysis --- p.119 === Chapter 4.2.9 --- Health-related Quality of Life Assessment --- p.120 === Chapter Chapter 5 --- Discussion and Conclusion === Chapter 5.1 --- Summary of Results --- p.123 === Chapter 5.2 --- Implication for Treatment --- p.126 === Chapter 5.3 --- Economic Evaluation --- p.129 === Chapter 5.4 --- Health-related Quality of Life --- p.132 === Chapter 5.5 --- Limitations of the Study --- p.134 === Chapter 5.6 --- Conclusion and Implications for Future Studies --- p.135 === Appendix --- p.137 === References --- p.139